Radical Numerics Says Omnii-1 Phages Given to Patient in First Clinical Use
Summary
Radical Numerics says phages designed by its Omnii-1 genome language model have been given to a patient with an antibiotic-resistant infection under a physician-led compassionate-use pathway, which the company calls the first clinical use of AI-generated phages. The company reports the cocktail cleared the patient's isolate in vitro but did not disclose outcomes.
Key Points
- Radical Numerics reports recovering 69.9% of Omnii-1 variants carrying 11 to 15 amino acid changes, against 4.8% of random controls.
- Omnii-1 reached 91.4% of 37 held-out E. coli clade strains with just two recommended phages, the company reports.
- The T7 engineering work uses a roughly 40-kilobase genome, over seven times the 5.4-kilobase ΦX174 phage behind EvoPhage.